Paracetamol toxicity Biochemical Basis Lecture Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity Acetaminophen toxicity EMCrit Project Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Paracetamol is one of the most commonly used analgesic and antipyretic drugs.
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glutathione depletion paracetamol Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90-95% gets broken down safely by glucuronidation + sulfation → non-toxic stuff you pee out. *The problem