Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. GutBrain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia Mast Cell Activation Syndrome Levitas Clinic Guildford Effects of cancer induced cachexia and administration of l glutathione on the intestinal mucosa in rat Amino Acids Springer Nature Link Mast Cell Activation Syndrome (MCAS) Dr. Todd Maderis