Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Why Does Glutathione Cause Acne Breakouts? Glamorous Dubai What to Avoid When Taking Glutathione: Glow Guide HK Vitals What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.