Can You Take Tylenol and Ibuprofen Together? Safety, Dosage, and Risks Explained HealthcareOnTime Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Avoid Tylenol with vaccines. A key reminder often emphasized in vaccine education is to avoid using Tylenol (acetaminophen) alongside vaccination. Tylenol requires glutathione for proper metabolism in the body. When glutathione Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy