G6PD enzyme mechanism and relationship with hydrogen peroxide Download Scientific Diagram G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No G6PD Deficiency and G6PD Activity Testing Mindray Role of Glucose 6 Phosphate Dehydrogenase (G6PD) in the Pathophysiol ogy of Cataract.