Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Tylenol And Glutathione Invigor Medical