The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Acetaminophen Use During Pregnancy and Autism Risk Tylenol And Alcohol: Dangers, Safe Alternatives & Treatment Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.