What to Avoid When Taking Glutathione Thornhill's Pharmacy Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Did you know that drugs like Tylenol and ibuprofen deplete the body's chief detoxifier, GLUTATHIONE? This is a BIG DEAL. Glutathione is essential not only for detox but also IMMUNE function,