Frontiers Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions Healing the Gut to Treat Psoriasis? Next Steps in Dermatology Orchestrated Cytokines Mediated by Biologics in Psoriasis and Its Mechanisms of Action Many treatment guidelines for psoriasis rely heavily on body surface area (BSA) involvement to determine disease severity and eligibility for systemic therapies like biologics. Traditionally, patients with less than 10% BSA involvementespecially Psoriasis harbors multiple pathogenic type 17 T cell subsets: Selective modulation by risankizumab Journal of Allergy and Clinical Immunology