Acetaminophen Toxicity: What Pharmacists Need to Know Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Pathway (therapeutic doses), Pharmacokinetics View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine