Comparing the Big 3, Semaglutide, Tirzepatide and Retatrutide : r Mounjaro Tirzepitide and Cagrilintide TikTok In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results CagriSema misses noninferiority vs tirzepatide in REDEFINE 4; Novo Nordisk shares fall 15% iPharmaCenter Cagrilintide: What It Is and How It's Being Studied for Weight Loss