Glutathione Benefits: The Antioxidant You've Never Heard Of Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Your liver's unsung hero: Glutathione Let's talk about what really happens when you take Tylenol (acetaminophen). Your liver breaks down acetaminophen through several pathways. One pathway creates NAPQIa reactive compound that needs Glutathione You Are The Healer