3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration NAPQI (N Acetyl 4 benzoquinone Imine) Acetaminophen Metabolite MedChemExpress Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione Chemical Research in Toxicology