Too Much Vitamin B12: Risks, Symptoms and When to Seek Help Bolt Pharmacy Is your B12 supplement causing your breakouts? It sounds like a paradox: you take vitamins to be healthy, but your skin starts acting up. While Vitamin B12 is essential for your Cortisone Shots for Acne: How They Work and Their Benefits GoodRx Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Vitamin B12 study hints at a molecular mechanism for acne pathogenesis The Pharmaceutical Journal