Initial Glutathione Depletion During Short Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the Glutamyl Cycle 5 Oxoprolinemia in a Patient With Severe Hypothyroidism and Chronic Acetaminophen Use Cureus Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione deplet Integrative Biology (RSC Publishing) DOI:10.1039 C3IB20245C The acetaminophen metabolite N acetyl p benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mecha Refractory high anion gap metabolic acidosis due to chronic paracetamol use: a case report Journal of Medical Case Reports Springer Nature Link
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5-oxoproline glutathione Full article: Identification of the γ-glutamyl cycle as a novel therapeutic target and 5-oxoproline as a new biomarker for diagnosing pancreatic cancer