Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Depletes Glutathione Essential Formulas Do you have questions about the use of Tylenol during pregnancy? We spoke with Dr. Janine Hutson, maternal fetal medicine specialist and OBGYN about what the latest research says, what to consider and Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower