Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells. Feline Iris Hyperpigmentation MSPCA Angell From melanocytes to melanomas Nature Reviews Cancer Melanotic Macule Lip TikTok Clinical features of cutaneous melanotic nevihead and neck region. a Download Scientific Diagram