Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Glucose 6 phosphate dehydrogenase (G6PD) deficiency Potential positive feedback loop involving the pentose phosphate Download Scientific Diagram Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease