What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Sex differences in glutathione metabolism and acetaminophen toxicity Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Acetaminophen metabolism Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: