In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are What is the mechanism of glutathione reductase when reducing oxidized glutathione? Quora Glutathione Synthesis and Turnover in the Human Erythrocyte Journal of Biological Chemistry L glutamine for sickle cell disease: more than reducing redox Annals of Hematology Springer Nature Link Simplify your Glutathione Measurements Arbor Assays