Breakthrough in studying the enzyme that ultimately produces fish odour syndrome Stabilizing the enzyme in fish odor syndrome Did You Know? Some people report a fishy smell after supplementing with L carnitine. This happens because certain gut bacteria convert carnitine to trimethylamine, a malodorous compound found in rotting fish. Trimethylaminuria, or fish odour syndrome is an uncommon condition that causes an unpleasant, fishy smell. The body is unable to turn a strong smelling chemical called trimethylamine produced in the gut when Breakthrough in studying the enzyme that ultimately produces fish odor syndrome EurekAlert!