Glutathione Depleting Pro Oxidant as a Selective Anticancer Therapeutic Agent ACS Omega Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione depletion mediated in situ transformation of Prussian blue nanocubes for enhanced tumor specific imaging and photoimmunotherapy Inorganic Chemistry Frontiers (RSC Publishing) Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect