Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Hot take: The skincare world told you vitamin b12 causes acne but yet your skin, brain, and hormones literally need it to function and everyone forgets to mention it's essential for detox, Too Much of a Good Thing: How Vitamin B12 Triggers Acne Breakouts How Long Does a Vitamin B12 Injection Last? Skin Benefits & More Vitamin B12 induced acneiform eruption ScienceDirect