Need another reason not to vape? Your oral health is at risk American Heart Association Oral mucosal ulceration a clinician's guide to diagnosis and treatment Let's Chat about Vaping Can vaping cause mouth ulcers? Vaping can cause canker sores or mouth ulcers There are many factors that can contribute to mouth ulcers, also known as canker sores. Vaping for just 12 months left woman, 22, with crusty herpes like ulcers so painful she couldn't eat or drink E cigarettes found to cause change in mouth bacteria which could lead to gum disease or oral cancer