Research indicates that certain flavoring chemicals used in e cigarettes can irritate lung tissue and trigger inflammatory responses in laboratory settings. Some compounds, such as diacetyl, have been linked to respiratory damage when Do Crystal Bar Vapes Have Diacetyl? Vapor Shop Direct Why Vape It? Poster NIMCO, Inc. Risk assessment of inhaled diacetyl from electronic cigarette use among teens and adults ScienceDirect UDM : .