Carnitine Shuttle Purpose and Mechanism YouTube The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Clinical Biochemistry department College of medicine AL Mustansiriyah University Dr. Ali al bayati Lipid metabolism L carnitine is primarily synthesized in the liver from the amino acids lysine and methionine through a series of four enzymatic reactions, with the liver and kidneys converting the precursor butyrobetaine into active Carnitine shuttle system and beta oxidation of fatty acids