Safe IM Injection Site Intramuscular injection should always be given in the **upper outer quadrant of the gluteal region** to prevent sciatic nerve injury. Key nursing points: Upper outer quadrant = How to Self Inject Vitamin B12 at Home The Sanctuary Wellness Institute Optimal B12 Injection Sites for Maximum Absorption and Benefits Your Health Magazine Intramuscular injection: Locations and administration Sites of Administration of Subcutaneous injection